Pre-implantation Genetic Diagnosis (PGD)
What is PGD?
Pre-implantation Genetic Diagnosis (PGD) is a revolutionary technique that combines recent advances in molecular genetics with assisted reproductive technology (ART). This innovative approach allows healthcare providers to identify genetic diseases in embryos before implantation, significantly enhancing the chances of having healthy children.
Why Choose PGD?
- Prevention of Genetic Diseases:
- PGD is particularly beneficial for couples with known genetic disorders or those with a family history of such conditions. It enables the selection of embryos free from these genetic issues, reducing the risk of transmission to the next generation.
- PGD is particularly beneficial for couples with known genetic disorders or those with a family history of such conditions. It enables the selection of embryos free from these genetic issues, reducing the risk of transmission to the next generation.

2. Early Detection:
- Unlike traditional methods such as amniocentesis or chorionic villus sampling, which are performed during pregnancy and may lead to difficult decisions if a genetic defect is detected, PGD allows for early identification of genetic abnormalities before implantation. This proactive approach helps couples avoid the emotional and physical challenges associated with potential pregnancy termination.
3. Improved Success Rates:
- By selecting genetically healthy embryos for implantation, PGD increases the chances of a successful pregnancy, reducing the likelihood of miscarriages and improving overall outcomes in assisted reproductive treatments.
How Does PGD Work?
- In Vitro Fertilization (IVF):
- The process begins with IVF, where eggs are retrieved from the ovaries and fertilized with sperm in a laboratory setting to create embryos.
- Embryo Biopsy:
- A few cells are carefully removed from each embryo (usually at the blastocyst stage) for genetic analysis. This biopsy does not harm the embryo and allows for thorough testing.
- Genetic Testing:
- The biopsied cells are analyzed for specific genetic defects or chromosomal abnormalities. Advanced techniques, such as PCR (Polymerase Chain Reaction) and next-generation sequencing, are used to obtain precise results.
- Embryo Selection:
- Based on the genetic testing results, only embryos free from identified genetic conditions are selected for transfer into the woman’s uterus.
- Embryo Transfer:
- The selected, healthy embryos are then implanted, with the hope of establishing a successful pregnancy.